The Acute Influence of Acid Suppression with Esomeprazole on Gastrointestinal Microbiota and Brain Gene Expression Profiles in a Murine Model of Restraint Stress.

•Stress and acid suppression independently and additively alter stomach microbiota.•Stress with acid suppression induces differential hippocampal gene expression.•Hippocampal gene expression is related to the distribution of gastric bacteria.•These altered expression of these genes may contribute to acute brain dysfunction.