Altered Expression Of Hormone Receptor, Integrin Beta 3 And Pinopode In The Endometrium Of Luteal Phase Defect Women

Objective: To invistigate estrogen receptor (ER), progesterone receptor (PR), integrin 3, and pinopode expression in luteal phase deficiency (LPD) women.Methods: There were 52 nulligravidas consecutive infertile patients undergoing a routine assistant reproduction consultation included in this study. An endometrial biopsy sample was randomly obtained between days 4 and 10 of the luteal phase. Endometrial morphology was examined with scanning electron microscopy. Expressions of ER, PR, integrin 3 were determined in the endometrium of LPD patients with immunohistochemistry.Results: The incidence of LPD was 15.3% (8/52) in this study. On day luteinizing hormone (LH) surge+9 approximate to LH+10, noted regressing pinopodes resembling a day LH+7 approximate to LH+8 in the endometrium of the control group. The expressions of ER and PR in glandular epithelium were significantly increased in endometrium of LPD than that in the control group (p<0.05). In contrast, there was a statistically significant decrease expression of the integrin 3 in women from the group of LPD (p<0.05).Conclusion: The altered expression of ER and PR may be associated with the expression variation of integrin and pinopode formation in endometrium of LPD women. This alteration may imply the association of low rates of cycle fecundity and high rates of embryonic loss in LPD women.