Measuring reproducibility of dose response data for the Pig-a assay using covariate benchmark dose analysis.

George E Johnson,Mika Yamamoto,Yuta Suzuki,Hideki Adachi,Takahiro Kyoya,Hironao Takasawa,Katsuyoshi Horibata, Eri Tsutsumi,Kunio Wada,Ryuta Kikuzuki,Ikuma Yoshida,Takafumi Kimoto,Akihisa Maeda,Kazunori Narumi

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2016）

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摘要

•Interlaboratory reproducibility is reasonable for in vivo Pig-a MF.•Covariate benchmark dose analysis provided a measure of reproducibility.•RBCs provided a greater level of Pig-a MF reproducibility and precision than RETs.•Reducing the number of zero values would increase overall reproducibility.

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关键词

OECD,Pig-a,Benchmark dose,Potency,In vivo,Dose response,Ring trial

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