In vitro assessment of biological activity and stability of the ALVAC-HIV vaccine.

Daniela Damjanovic,Liwei He, Julie Symes,Beata Gajewska,Ali Azizi,Danielle Salha,Luciano Ettorre, Lidice Bernardo-Reyes,Jin Su,Sanjay Phogat,Lucy Gisonni-Lex

Vaccine（2018）

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摘要

•High-throughput biological activity assay for characterization of ALVAC-HIV vaccine.•Results correlate with infectious titer assay, the vaccine quantitative release test.•Assay is specific, accurate, precise, stability-indicating, and robust.•Utilizes biologically functional human anti-gp120 monoclonal antibodies.•Used for characterization of ALVAC-HIV vaccine in pivotal HVTN702 study.

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关键词

HIV,Clinical trial,Canarypox virus,Vaccine,Relative activity,Stability

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