Effect of ferric citrate on amyloid-beta peptides behavior.
BIOPOLYMERS(2018)
摘要
Amyloid beta (A) aggregation and oxidative stress are two of the central events in Alzheimer's Disease (AD). Both these phenomena can be caused by the interaction of A with metal ions. In the last years the interaction between Zn-II, Cu-II, and A was much studied, but between iron and A it is still little known. In this work we determine how three A peptides, present in AD, interact with Fe-III-citrate. The three A peptides are: full length A1-42, an isoform truncated at Glutamic acid in position three, A3-42, and its pyroglutamated form ApE3-42. Conformation and morphology of the three peptides, aggregated with and without Fe-III-citrate were studied. Besides, we have determined the strength of the interactions A/Fe-III-citrate studying the effect of ethylenediaminetetraacetic acid as chelator. Results reported here demonstrate that Fe-III-citrate promotes the aggregation in all the three peptides. Moreover, Aspartic acid 1, Glutamic acid 3, and Tyrosine 10 have an important role in the coordination with iron, generating a more stable complex for A1-42 compared to that for the truncated peptides.
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关键词
Aggregation,Alzheimer's Disease,amyloids,iron,N-truncated peptides,pyroglutamated A
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