Comparative pharmacokinetics of diaveridine in pigs and chickens following single intravenous and oral administration.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS(2017)
摘要
Comparative pharmacokinetic profiles of diaveridine following single intravenous and oral dose of 10mg/kg body weight in healthy pigs and chickens were investigated, respectively. Concentrations of diaveridine in plasma samples were determined using a validated high-performance liquid chromatography-ultraviolet (HPLC-UV) method. The concentration-time data were subjected to noncompartmental kinetic analysis by WinNonlin program. The corresponding pharmacokinetic parameters in pigs or chickens after single intravenous administration were as follows, respectively: t(1/2) (elimination half-life) 0.74 +/- 0.28 and 3.44 +/- 1.07h; V-d (apparent volume of distribution) 2.70 +/- 0.99 and 3.86 +/- 0.92L/kg; Cl-B (body clearance) 2.59 +/- 0.62 and 0.80 +/- 0.14L/h/kg; and AUC(0-) (area under the blood concentration vs. time curve) 4.11 +/- 1.13 and 12.87 +/- 2.60g.h/mL. The corresponding pharmacokinetic parameters in pigs or chickens after oral administration were as follows, respectively: t(1/2) 1.78 +/- 0.41 and 2.91 +/- 0.57h; C-max (maximum concentration) 0.43 +/- 0.24 and 1.45 +/- 0.57g/mL; T-max (time to reach C-max) 1.04 +/- 0.67 and 3.25 +/- 0.71h; and AUC(0-)1.33 +/- 0.55 and 9.28 +/- 2.69g.h/mL. The oral bioavailability (F) of diaveridine in pigs or chickens was determined to be 34.6% and 72.2%, respectively. There were significant differences between the pharmacokinetics profiles in these two species.
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关键词
diaveridine,comparative pharmacokinetics
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