Re-randomization increased recruitment and provided similar treatment estimates as parallel designs in trials of febrile neutropenia.

Brennan C Kahan,Tim P Morris, Erica Harris,Rupert Pearse,Richard Hooper,Sandra Eldridge

Journal of Clinical Epidemiology（2018）

引用 5|浏览9

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摘要

In the setting of febrile neutropenia, re-randomization increased recruitment whilst providing similar estimates of treatment effect to parallel group trials, with minimal loss-to-follow-up or non-compliance. It appears to be safe and efficient alternative to parallel group designs in this setting.

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关键词

Re-randomization,Randomized controlled trials,Clinical trials,Febrile neutropenia,Re-enrolment,Poor recruitment

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