Allelic and haplotype diversity of 12 X-STRs in the United Arab Emirates.

X-chromosomal short tandem repeats (X-STRs) are used to complement autosomal and Y-STRs in complex kinship testing, and can be of potential value when determining trace female DNA in male background. We analyzed extracted and directly-amplified samples of 501 males from the United Arab Emirates and report the forensic statistical parameters of 12 X-STRs and haplotypes of the four previously defined linkage groups using the Investigator Argus X-12 QS kit. Combined PDM, PDF, MEC Desmarais Trio and MEC Desmarais Duo based on allele (and haplotype) frequencies were 0.9999999997 (0.999999996), >0.9999999999 (>0.999999999), 0.999999999 (0.999999996) and 0.9999997 (0.99999994) respectively. No shared profile was observed, and significant linkage disequilibrium was detected only within the four linkage groups. We calculated pairwise genetic distance (FST) between our Emirati sample and 35 populations and find they generally mirror biogeography and historical relationships. We identified 20 distinct off-ladder alleles in seven loci, the majority of which at DXS10148 and DXS10134. Our analysis reveals that the 12 loci are informative and discriminatory in the Emirati population.