Mutual Effect Of Cerebral Amyloid And Peripheral Lymphocytes In Cognitively Normal Older Individuals

ObjectiveWe hypothesized that cerebral amyloid accumulation is reflected in the periphery in the pre-dementia stage and used flow cytometry to investigate the peripheral lymphocytes as an easily accessible biomarker to observe neuro-inflammation. We aimed to determine whether peripheral lymphocytes are related to the cortical amyloid burden or vice versa in cognitively normal older subjects.MethodsWe applied [C-11] Pittsburgh compound B (PiB)-positron emission tomography to 36 cognitively normal older individuals, and A deposition was quantified by cortical binding potential (PiB-BPND). Blood samples were obtained, and lymphocyte subsets were evaluated. We examined differences between low and high PiB-BPND groups in the percentage of B cells, T cells, helper T cells, cytotoxic T cells, regulatory T cells, and natural killer cells(.)ResultsSubjects with high PiB-BPND showed significantly higher percentage of cytotoxic T cells (%CD3(+)). Correlation analysis revealed a significant relationship between the percentage of cytotoxic T cells and global cortical mean PiB-BPND. Hierarchical regression analyses showed that cytotoxic T cells were significantly related to the value of global cortical mean PiB-BPND and vice versa.ConclusionsOur results indicated that a specific peripheral immune response, reflected in the increased ratio of cytotoxic T cells, could be regarded as a preclinical sign of AD and could be attributed to the A neuropathological mechanism. Copyright (c) 2017 John Wiley & Sons, Ltd.