Actively Controllable Stem Cell Spheroid-based Microrobot for Tissue Regeneration
2018 7TH IEEE INTERNATIONAL CONFERENCE ON BIOMEDICAL ROBOTICS AND BIOMECHATRONICS (BIOROB2018)(2018)
摘要
In this paper, actively controllable stem cell spheroid-based microrobot is proposed to improve targeting the stem cells to specific desired sites using external electromagnetic actuation (EMA) system. Mouse mesenchymal stem cell (MSCs) were labeled with 0.2 mg/ml magnetic nanoparticles (MNPs) and no cytotoxicity was observed up to MNPs concentration of 0.2 mg/ml on 2D and 3D culture. The stem cell spheroids were fabricated with diameters of 353.62 tm 24.61 (1VINP unlabeled) and 336.84 tm 28.2 (MNP labeled) by ultra-low attachment plate culture. In addition, mouse MSCs spheroids were actively controlled by the EMA system. Therefore, these results demonstrated that stem cell spheroid-based microrobot can be potential therapeutic agent for tissue regeneration or repairing, such as, articular cartilage regeneration.
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关键词
actively controllable stem cell spheroid-based microrobot,tissue regeneration,external electromagnetic actuation system,mouse mesenchymal stem cell,stem cell spheroids,mouse MSCs spheroids,magnetic nanoparticle,EMA system,3D culture,2D culture,articular cartilage regeneration,ultralow attachment plate culture
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