Is there an association between cortisol and hypertension in overweight or obese children?
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY(2017)
摘要
Objective: The precise mechanisms behind the development of hypertension in overweight or obese children are not yet completely understood. Alterations in hypothalamic-pituitary-adrenal axis activity may play a role. We aimed to investigate the association between cortisol parameters and hypertension in overweight or obese children. Methods: Random urine (n = 180) and early-morning saliva samples (n = 126) for assessment of cortisol and cortisone were collected from 1) hypertensive overweight children (n = 50), 2) normotensive overweight children (n = 145), and 3) normotensive non-overweight children (n = 75). Results: The age of participants was 10.4 +/- 3.3 years and 53% were boys. The urinary cortisol-to-cortisone ratio [beta 1.11, 95% confidence interval (CI) 1.05-1.19] as well as urinary cortisol/creatinine (beta 1.38, 95% CI 1.09-1.54), and cortisone/creatinine ratios (beta 1.26, 95% CI 1.17-1.36) were significantly higher in overweight or obese than in non-overweight children. After adjusting for body mass index-standard deviation score and urinary cortisone/creatinine ratio, but not cortisol/creatinine ratio, was significantly associated with presence of hypertension (beta 1.12, 95% CI 1.02-1.23). Salivary cortisol and cortisone levels were significantly lower in overweight or obese than in non-overweight children (beta -4.67, 95% CI -8.19-1.15, and beta 0.89, 95% CI 0.80-0.97 respectively). There were no significant differences in cortisol parameters between hypertensive and normotensive overweight or obese children. Conclusion: This study provided further evidence for an increased cortisol production rate with decreased renal 11 beta-hydroxysteroid dehydrogenase 2 activity and flattening of early-morning peak cortisol and cortisone in overweight or obese children. However, there were no significant differences in cortisol parameters between hypertensive and normotensive overweight and obese children.
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关键词
Hypertension,obesity,children,cortisol,pathophysiology
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