Effects of race and sex on cerebral hemodynamics, oxygen delivery and blood flow distribution in response to high altitude
SCIENTIFIC REPORTS(2016)
摘要
To assess racial, sexual and regional differences in cerebral hemodynamic response to high altitude (HA, 3658 m). We performed cross-sectional comparisons on total cerebral blood flow (TCBF = sum of bilateral internal carotid and vertebral arterial blood flows = Q ICA + Q VA ), total cerebrovascular resistance (TCVR), total cerebral oxygen delivery (TCOD) and Q VA /TCBF (%), among six groups of young healthy subjects: Tibetans (2-year staying) and Han (Han Chinese) at sea level, Han (2-day, 1-year and 5-year) and Tibetans at HA. Bilateral ICA and VA diameters and flow velocities were derived from duplex ultrasonography; and simultaneous measurements of arterial pressure, oxygen saturation and hemoglobin concentration were conducted. Neither acute (2-day) nor chronic (>1 year) responses showed sex differences in Han, except that women showed lower TCOD compared with men. Tibetans and Han exhibited different chronic responses (percentage alteration relative to the sea-level counterpart value) in TCBF (−17% vs . 0%), TCVR (22% vs . 12%), TCOD (0% vs . 10%) and Q VA /TCBF (0% vs . 2.4%, absolute increase), with lower resting TCOD found in SL- and HA-Tibetans. Our findings indicate racial but not sex differences in cerebral hemodynamic adaptations to HA, with Tibetans (but not Han) demonstrating an altitude-related change of CBF distribution.
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关键词
Blood flow,Environmental impact,Medical research,Metabolomics,Vasodilation,Science,Humanities and Social Sciences,multidisciplinary
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