Soluble sortilin is released by activated platelets and its circulating levels are associated with cardiovascular risk factors.

•Human platelets released soluble sortilin (sSortilin) upon activation.•Aspirin inhibited the release of sSortilin together with platelet aggregation.•Levels of plasma sSortilin were increased in cardiovascular risk patients.•Plasma sSortilin showed significant correlations to cardiovascular risk factors.•Elevated plasma sSortilin levels could be a risk factor for atherothrombosis.