BSPAR ANNUAL CONFERENCE ABSTRACTS * Oral presentations * O1. The impact of modern management on outcomes of JIA compared with healthy controls

Background: Development of modern therapeutic approaches over the last decade has improved short-term well-being in JIA patients. This study examines disease damage and body composition (BC). Aims: Comparison of JIA patients' clinical well-being with matched controls assessing BC, cross-sectional inflammatory markers and the levels of joint and uveitis-associated damage relating to their management. Methods: 112 JIA patients (disease duration ≥5 years) were cross-sectionally compared with 127 age, sex, ethnicity and deprivation score-matched controls, measuring inflammatory markers (hsCRP, IL-6 and ICAM-1), growth and BC [height, weight, fat mass (FM/H(2)), free fat mass (FFM/H(2)), BMI and skinfold thickness]. Clinical examination recorded disease damage, supported by case-note review. Results: Compared with controls, patients 16 years had higher hsCRP, ICAM-1 and IL-6 (P 22 years. Of 90 patients, Group A never required DMARDs, Group B had modern therapeutic approaches [prompt MTX (SSZ in 1) and rapid escalation to biologics] and Group C had late DMARDs/biologics intervention despite persistent inflammation. Feet, knees and temporomandibular joints were most commonly damaged. A positive correlation was found between delay in starting modern therapy and severest joint damage outcome (Table 1). Conclusions: It is of new concern that high obesity levels in the youngest patients were significantly greater than in controls. Normal inflammatory markers, reduced frequency and severity of joint damage but high complication rates of chronic anterior uveitis (CAU) were associated with modern therapeutic approaches. Disclosure statement: The authors have declared no conflict of interest. Table 1Damage to joints and eyes by disease management ManifestationA (n = 16)B (n = 59)C (n = 15)Joint damage    None14401    Radiological change only020    Minimal restriction293    Functional disability087    Joint replacement (hip and or knee)004    CAU ever285    Complications of CAU044    Cataract34    Glaucoma42    Permanent visual impairment21    Band keratopathy12    Posterior synechiae11.