Algorithm that delivers an individualized rapid‐acting insulin dose after morning resistance exercise counters post‐exercise hyperglycaemia in people with Type 1 diabetes

AimsTo develop an algorithm that delivers an individualized dose of rapid-acting insulin after morning resistance exercise to counter post-exercise hyperglycaemiain individuals with Type 1 diabetes. MethodsEight people with Type 1 diabetes, aged 347years with HbA(1c) concentrations 7212mmol/mol (8.71.1%), attended our laboratory on two separate mornings after fasting, having taken their usual basal insulin the previous evening. These people performed a resistance exercise session comprising six exercises for two sets of 10 repetitions at 60% of the maximum amount of force that was generated in one maximal contraction (60% 1RM). In a randomized and counterbalanced order, the participants were administered an individualized dose of rapid-acting insulin (21 units, range 0-4 units) immediately after resistance exercise (insulin session) by means of an algorithm or were not administered this (no-insulin session). Venous blood glucose concentrations were measured for 125min after resistance exercise. Data (mean sem values) were analysed using anova (P0.05). ResultsParticipants had immediate post-resistance exercise hyperglycaemia (insulin session 13.0 +/- 1.6 vs. no-insulin session 12.7 +/- 1.5mmol/l; P=0.834). The decline in blood glucose concentration between peak and 125min after exercise was greater in the insulin exercise session than in the no-insulin session (3.3 +/- 1.0 vs. 1.3 +/- 0.4mmol/l: P=0.015). There were no episodes of hypoglycaemia (blood glucose <3.9mmol/l). ConclusionsAdministration of rapid-acting insulin according to an individualized algorithm reduced the hyperglycaemia associated with morning resistance exercise without causing hypoglycaemia in the 2h post-exercise period in people with Type 1 diabetes.