Phenotypic Differences in Three Families With Hereditary Gingival Fibromatosis

Hereditary gingival fibromatosis (HGF) is a rare genetic condition (1:750.000). Its expression may vary from mild to severe. Clinically, there is slow and continuous gingival overgrowth that may lead to partial or full coverage dental clinic crowns. This study presents clinical, radiographic, and histological comparisons between members of three distinct families. Two conditions are observed: individuals who have an exuberant growth with partial coverage of dental crowns and individuals who have only discreet growth. Radiographically, there are no changes, and the transmission pattern is autosomal dominant in three families. Histologically, the epithelium has long, slender ridges that protrude into the underlying connective tissue, which is characterized by dense, thick collagen fiber bundles. Because HGF may present a variety of clinical aspects, it is important to associate all aspects—clinical, radiographic, and histological—so that tenuous HGF cases do not remain undiagnosed. Acknowledgement: FAPEMIG.