Giant Cell Fibroma: A Case Report Concerning an Unusual Lesion of the Oral Cavity

Aims: We describe the case of a young man with giant cell fibroma (GCF) of the oral cavity. Cases such as this are rare and we believe that our research adds to the literature concerning this area of study. Presentation of the Case: An asymptomatic, sessile lesion was excised from the tongue of a young man who had no previous history of chronic irritation. The final diagnosis was GCF and no recurrences have been reported to date. Discussion: GCF is a debated lesion, clinically indistinguishable from other benign lesions of the oral cavity. Large, stellate and multinucleated giant cells in a loose, poorly vascularized stroma are characteristic histological features that differentiate it from other fibrous lesions. Our case was negative for CD34 and positive for vimentin and factor XIIIa, which supports origin from a subpopulation of fibroblasts that are normally resident in the oral cavity. Conclusion: Our findings further support the view that GCF should be classified as a distinct entity.