Diversity and Frequencies of HLA Class I and Class II Genes of an East African Population
Open Journal of Genetics(2014)
摘要
Human Leukocyte
Antigens (HLAs) play an important role in host immune responses to infectious
pathogens, and influence organ transplantation, cancer and autoimmune diseases.
In this study we conducted a high resolution, sequence-based genotyping of HLA
class I and class II genes of more than 2000 women from Kenya, eastern Tanzania
and southern Uganda around Lake Victoria and analyzed their allele, phenotype
and haplotype frequencies. A considerable genetic diversity was observed at
both class I and II loci. A total of 79 HLA-A, 113 HLA-B, 53 HLA-C, 25 HLA-DPA1,
60 HLA-DPB1, 15 HLA-DQA1, 44 HLA-DQB1 and 38 HLA-DRB1 alleles have been
identified. The most common class I alleles were A * 02:01:01 (10.90%), B *
58:02 (8.79%), and C * 06:02:01 (16.98%). The most common class II alleles were
DPA1*01:03:01 (40.60%), DPB1 * 01:01:01 (23.45%), DQA1 * 01:02:01 (31.03%),
DQB1 * 03:01:01 (21.79%), DRB1 * 11:01:02 (11.65%), DRB3 * 02:02:01 (31.65%),
DRB4 * 01:01:01 (10.50%), and DRB5 * 01:01:01 (10.50%). Higher than expected
homozygosity was observed at HLA-B (P = 0.022), DQA1 (P = 0.004), DQB1 (P = 0.023),
and DRB1 (P = 0.0006) loci. The allele frequency distribution of this
population is very similar to the ones observed in other sub-Saharan
populations with the exception of lower frequencies of A * 23 (5.55% versus
11.21%) and DQA1 * 03 (4.79% versus 11.72%), and higher frequencies of DPB1 *
30 (2.26% versus 0.37%) and DRB1 * 11 (21.51% versus 15.89%). The knowledge of
the diversity and allele/ phenotype frequencies of the HLA alleles of this east
African population, can contribute to the understanding of how host genetic
factors influence disease susceptibility and effective anti-retroviral
treatment of HIV infections and future vaccine trials.
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关键词
hla b
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