Prognostic impact of clinic, daytime, and nighttime systolic blood pressure in 9 cohorts of 13,843 patients with hypertension: systematic review and meta-analysis

SBP and a 10 mmHg increase in SBP. Meta-regression and subgroup analyses were used to quantify the relative prognostic value of women versus men. Patients were from Europe, Brazil, and Japan (10 cohorts, N1⁄417,312, CVEs1⁄41,892). One cohort lacked gender-specific HRs from 24 hour and clinic SBP but otherwise had gender-specific information. There was a tendency for women to have a greater 1 SD of SBP and a greater coefficient of variation as compared to men. For women relative to men, a 1 SD increase in nighttime, daytime, 24 hour, and clinic SBP, gave RRs (95% confidence intervals) of 1.18 (1.05-1.31), 1.23 (1.09-1.40), 1.21 (1.07-1.37), and 0.94 (0.83-1.06), respectively. (See Figures.) For a 10 mmHg increase in SBP, the corresponding RRs were 1.06 (0.99-1.14), 1.13 (1.03-1.23), 1.10 (1.01-1.21), and 0.96 (0.89-1.03), respectively. In conclusion, in patients with hypertension, ambulatory SBPs better predict CVEs in women than in men.