A chemoenzymatic synthesis of the 12-membered macrolide (−)-cladospolide A

Martin G Banwell,Katrina A Jolliffe,David T J Loong,Kenneth J Mcrae,Filisaty Vounatsos

Journal of The Chemical Society-perkin Transactions 1（2002）

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摘要

The enantiomerically pure cis-1,2-dihydrocatechol 7, which is obtained by microbial oxidation of chlorobenzene, has been converted, via a sequence of reactions including ring-closing metathesis and Yamaguchi lactonisation steps, into the natural product (−)-cladospolide A (1).

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关键词

chemical bonds,enzymes,filtration,oxidation,aromatic compounds,fermentation,mixtures,stereochemistry

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