Facile Synthesis, Characterization, And In Vitro Antimicrobial Screening Of A New Series Of 2,4,6-Trisubstituted-S-Triazine Based Compounds

A series of new 2,4,6-trisubstituted-s-triazine was synthesized, assessed for antimicrobial activity, and characterized by FTIR, (HNMR)-H-1, (CNMR)-C-13, and elemental analysis. The tested compounds, 4d, 4g, 4h, 4k, and 4n, have shown considerable in vitro antibacterial efficacy with reference to the standard drug ciprofloxacin (MIC 3.125 mu gmL(-1) against B. subtilis, E. coli, and K. pneumoniae). It was observed that compounds 4d and 4h displayed equipotent antibacterial efficacy against B. subtilis (MIC 3.125 mu gmL(-1)) and S. aureus (MIC 6.25 mu gmL(-1)). The studies demonstrated that the para-fluorophenylpiperazine substituted s-triazine (4n) was potent and exhibited broad spectrum antibacterial activity against S. epidermidis, K. pneumoniae, and P. aeruginosa with MIC of 6.25 mu gmL(-1) and for E. coli, it showed an MIC of 3.125 mu gmL(-1) equipotent with reference to the standard drug. Among all the compounds under investigation, compound 4g also demonstrated significant antifungal activity (3.125 mu gmL(-1)) against C. albicans.