Propensity Score-Matched Lesion-Based Comparison Of Mid-Term Angiographic Outcomes Of Taxus Liberte With Cypher Bx Velocity Stents For De Novo Native Coronary Stenosis And In Patients With Diabetes

Objective We sought to perform a propensity score-matched lesion-based comparison of mid-term angiographic outcomes of sirolimus-(SES, Cypher Bx Velocity) and paclitaxel-(PES, TAXUS Libert, the 2nd-generation TAXUS) eluting stents to treat de novo coronary stenosis and, particularly, in patients with diabetes mellitus (DM) in a daily practice environment.Methods The present study was a non-randomized, retrospective, lesion-based, single center study that included 1,287 de novo native coronary stenosis cases after successful SES or PES placement between February 2007 and April 2011. The primary endpoint was angiographic-based binary in-stent restenosis (% diameter stenosis > 50 at secondary angiogram) within 550 days of placement. A propensity score-matched analysis was used to adjust the baselines.Results Among 360 baseline-adjusted angiographic lesions followed up in each arm, the incidence of the primary endpoint in the PES group (11.7%, follow-up period: 350 +/- 76 days) was not significantly different from that in the SES group (10.3%, p=0.645, 354 +/- 81 days, p=0.912). PES was not associated with the primary endpoint by logistic regression analysis (odds ratio: 1.15, 95% confidence interval: 0.68-1.93, p=0.605). In the DM specific sub-analysis, the primary endpoint in the PES group (19.6%) was not significantly different from that in the SES group (12.8%, p=0.105) in 148 baseline-adjusted lesions in each arm.Conclusion The mid-term angiographic outcomes after TAXUS Libert, placement for all-comer de novo native coronary stenosis and in patients with DM were not significantly different from those of SES in a Japanese daily practice environment.