Effect of obesity on in-hospital treatment for acute coronary syndrome complicated by new-onset heart failure.

Objective Obesity has been associated with superior outcomes in heart failure (HF) and acute coronary syndrome (ACS). Although patients with new-onset HF after ACS are at a high risk, they may receive less aggressive treatment. It is unknown whether treatment practices are biased by BMI. Methods and results Consecutive patients without previous HF, who were hospitalized with ACS, and had left ventricular ejection fraction less than 40% or clinical HF were analyzed to assess the utilization of evidence-based treatment by BMI. BMI was categorized into normal (18.5 to <25 kg/m(2)), overweight (25 to <30 kg/m(2)), and obese (>= 30 kg/m(2)) groups. Multivariable logistic regression models were performed to examine the association of BMI with undergoing cardiac catheterization, and discharge on beta-blocker or angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB). Analysis included 461 patients. There were no significant differences among BMI groups in performance of cardiac catheterization or discharge on ACE inhibitor/ARB or beta-blocker. Compared with normal, neither overweight nor obese BMI was significantly associated with cardiac catheterization [overweight: odds ratio (OR) 1.49, 95% confidence interval (CI) 0.82-2.72, P = 0.2; obese: OR 1.75, 95% CI 0.92-3.33, P = 0.09], or discharge on ACE inhibitor/ARB (overweight: OR 0.70, 95% CI 0.40-1.21, P = 0.7; obese: OR 0.69, 95% CI 0.39-1.23, P = 0.2), or beta-blocker (overweight: OR 1.24, 95% CI 0.69-2.21, P = 0.5; obese: OR 1.13, 95% CI 0.62-2.07, P = 0.7). Conclusion Among patients with new-onset HF complicating ACS, there were no significant differences in evidence-based treatment practices by BMI. Coron Artery Dis 24:279-284 (c) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.