Synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine via sequential radical processes.
ORGANIC & BIOMOLECULAR CHEMISTRY(2013)
摘要
An efficient synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine is described (6 steps and 50% overall yield). The two phosphorus-carbon bonds in the perifosine analogue were prepared by sequential double radical hydrophosphinylation processes. This is the first example of a phosphinate analogue of perifosine, designed to be resistant to hydrolysis by phospholipid-metabolizing enzymes.
更多查看译文
关键词
phosphinate analogue,synthesis,anti-tumour,di-ester
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要