Cerebrovascular metabolic autoregulation is impaired during liver transplantation.

Background. We determined whether the coupling between cerebral blood flow (CBF) and oxygen metabolism (CMRO2) is preserved during liver transplantation. Because of cerebrovascular dilatation, we hypothesized that cerebral metabolic autoregulation is impaired, because CBF becomes uncoupled from CMrO(2) during the reperfusion phase of the operation. Materials and Methods, In a prospective study, 13 patients (8 women, median age 46, range 21-56) with liver failure (10 with end-stage chronic liver disease and 3 with acute liver failure) were enrolled, Catheters were placed in a femoral artery and in the internal jugular vein for calculation of the cerebral arteriovenous oxygen content difference (AVDO(2)). CBF was recorded by the (133)Xenon injection technique, and by transcranial Doppler sonography determined mean flow velocity (V-mean)in the middle cerebral artery; The CMRO2 was calculated as the AVDO(2) times CBF and the cerebrovascular resistance (CVR) as the mean arterial pressure to CBF ratio. An index of large cerebral artery diameter was expressed by the CBF to Vmean ratio. Results From induction of anesthesia to the anhepatic period, CBF decreased from a median of 47 (interquartiles 31-55) to 41 (87-88) ml 100 g(-1) min(-1), whereas the CMRO2 remained unchanghed (1.3 [0.9-2.5] vs, 1.7 [0.9-2.3] ml 100 g(-1) min(-1)). In the reperfusion phase, the CBF increased to 51 (45-54) ml 100 g(-1) min(-1), whereas the CMRO2 remained unchanged at 1.1 (1.0-2.5) ml 100 g(-1) min(-1). The CVR decreased from 2.0 mm Mg (1.4-2.1) to 1.4 (1.1-1.8) mm Hg-1 min 100 g ml. In the anhepatic phase, mean arterial pressure decreased from 92 mm Mg (84-98) to 85 (80-92) mm Mg and at reperfusion it was 80 (71-105) mm Mg, From the anhepatic to the reperfusion phase, the CBF increased 7% (0 to 26) for each mpn Mg concomitant increase in PalCO(2),. The CBF to V-mean ratio remained stable (1.0 [0.8-1.2] vs. 0.9 [0.7-1.1] ml 100 g(-1) min(-1) cm(-1) sec). Conclusion. During the reperfusion phase of liver transplantations, cerebrovascular dilatation uncouples cerebral oxidative metabolism from blood flow. The increase in CBF is beyond what can be explained by changes in arterial carbon dioxide tension and arterial pressure.