Quantitative analysis of rate-dependent of human heart failure action potential model on alternans onset and arrhythmias
CinC（2014）
摘要
It is known that at the living organism level, heart failure (HF) increases the susceptibility to and incidence of cardiac alternans, both of which are strongly associated with sudden cardiac death (SCD). We use mathematical models to investigate how electrophysiological properties consistent with heart failure affect the onset and magnitude of electrical alternans and its mechanism compared to similar cases in normal human cells. We study how APD restitution curves and short-term memory are altered in normal and HF-affected cells and tissue. We compare our results with available experimental observations and find good agreement.
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关键词
bioelectric potentials,biomembranes,brain,cardiology,cellular biophysics,differential equations,diseases,medical computing,neurophysiology,apd restitution curves,hf action potential model,hf-affected cells,hf-affected tissues,scd-associated cardiac alternans,action potential duration restitution curves,action potential model rate dependence,alternans ap model rate dependence,arrhythmia ap model rate dependence,cardiac alternans incidence,cardiac alternans susceptibility,electrical alternans magnitude,electrical alternans mechanism,electrical alternans onset,heart failure electrophysiological properties,human heart failure action potential model,mathematical models,normal human cells,quantitative rate dependence analysis,short-term memory,sudden cardiac death,heart,computational modeling,hafnium,mathematical model,bifurcation,steady state
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