Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts and abnormal promyelocytes

Cancer cell international(2014)

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摘要
Background There is limited information on a special subtype of Acute myeloid leukemia (AML) characterized by >20% myeloblasts and >20% abnormal promyelocytes in bone marrow and peripheral blood. Objective The objective of the present investigation was to explore the clinical and laboratory features of seven patients with AML-M2/M3. Method We retrospectively assessed cell morphology, cytochemistry, immunophenotype, cytogenetics, and clinical features of seven patients with this rare subtype of AML. Results All seven cases had thrombocytopenia, coagulation abnormalities, >20% myeloblasts and abnormal promyelocytes. The PML/RARα fusion gene was present in six patients and two patients presented a mixed PML/RARα and AML1/ETO genotype. Five cases achieved CR and two cases did not achieve remission and one case transform into AML-M2 after CR 1 . Conclusions The clinical and laboratory features of seven patients with AML-M2/M3 are demonstrated in the present study, providing information on the FAB sub-classification.
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关键词
aml-m2/m3 subtype,abnormal promyelocytes,acute myeloid leukemia (aml),mixed phenotype,myeloblasts,Acute myeloid leukemia (AML),AML-M2/M3 subtype,Mixed phenotype,Myeloblasts,Abnormal promyelocytes
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