The difference of BMD between premature ovarian failure and natural menopausal women and the efficacy of tibolone

Objective: To investigate the differences of bone mineral density (BMD) between premature ovarian failure (POF) and natural menopausal women and observe the results of treatment with tibolone. Methods: Sixty-three cases of diagnosed by osteoporosis were divided into three groups: 29 cases of POF were group A with the age of 48-76(62 ± 7.0); 34 cases of natural menopausal were group B with the age of 52-77 (63.4 ± 6.0); 32 out of 63 cases were treated by tibolone (Livial™ 1.25mg/d for 6 months) as group C. The dual energy X-ray absorptiometry (Hologic, QDR-4500-W) was used to determine the BMD of lumbar vertebrae and femoral neck in group A and group B and determine the BMD before and after treatment in group C. Results: There were significant differences of BMD of L 2-4 and femoral neck between, group A and group B (P <0.05). The BMD before and after treatment had significant differences in group C (P <0.01) and the average rate of increase was 2.7% and 2.2% respectively. Conclusion: The bone loss of POF is early and more than that of natural menopausal women. The BMD of postmenopausal women are increased obviously by treating with tibolone.