Clinical significance of differential expression of VEGF 165b between colorectal cancer and normal intestinal mucosa tissues

AIM: To investigate the differential expression of vascular endothelial growth factor (VEGF) 165b between colorectal cancer (CRC) and normal intestinal mucosa tissues and its role in the development of CRC. METHODS: Real-time qRT-PCR was performed to detect the expression of VEGF 165b mRNA in 20 fresh CRC tissues and 20 matched normal intestinal mucosa tissues. Statistical methods were used to compare the expression of VEGF 165b in CRC tissues and normal intestinal mucosa tissues; tissues inside and outside the serosal layer; tissues with and without lymph node metastasis; tissues of TNM stages II and III tumors. RESULTS: The positive expression rate of VEGF l65b mRNA in normal intestinal mucosa tissues was significantly higher than that in CRC tissues (P = 0.006). The expression of VEGF 165b was not statistically significant between CRC tissues and normal intestinal mucosa tissues, between tissues inside and outside the serosal layer, between tissues with and without lymph node metastasis, or tissues between TNM stages II and III tumors. CONCLUSION: VEGF 165b might play a role in inhibiting the development of CRC and provide a new target for the diagnosis, prognosis and treatment of this malignancy. ? 2014 Baishideng Publishing Group Co., Limited. All rights reserved.