Expression of osteopontin in ovarian serous cystadenocarcinoma tissues and its clinical significance

Objective: To investigate the expression of osteopontin (OPN) in ovarian serous cystadenocarcinoma tissues and explore the relationship with clinicopathological characteristics. Methods: The expressions of OPN in 70 cases of ovarian serous cystadenocarcinoma tissues, 22 cases of ovarian serous cystadenoma tissues, and 15 cases of normal ovarian tissues were detected by immunohistochemistry method. Results: Circled digit one The positive expression rate of OPN in ovarian serous cystadenocarcinoma tissues was 82.9%, much higher than those in ovarian serous cystadenoma tissues (22.7%) and nomal ovarian tissues (13.3%) (P<0.05). Circled digit two The positive expression rates of OPN in stage I , stage II, stage III, stage IV ovarian serous cystadenocarcinoma tumor tissues were 60.0%, 76.2%, 96.2%, and 100.0%. The positive rate of OPN expression in stage III and IV tumor tissues (97.1%) was dramatically higher than that in stage I and stage II (69.4%) (P<0.05). The positive expression rates of OPN in G 1, G 2, and G 3 ovarian serous cystadenocarcinoma tumor tissues were 74.1%, 80.0% and 95.7%, it was dramatically higher in G 3 tumor tissues than that in G 1 tumor tissues (P<0.05). There was correlation between the positive rate of OPN and pathological grading and clinical stages, the later clinical stage and the worse differentiation of ovarian serous cystadenocarcinoma, the stronger positive expression rate of OPN. Circled digit three The positive expression rate of OPN in ovarian serous cystadenocarcinoma tumor tissues with ascites (95.2%) was higher than that in tumor tissues without ascites (64.3%) (P<0.05). Conclusion: Overexpression of OPN may promote the development, invasion and metastasis of ovarian serous cystadenocarcinom. The detection of OPN can be used as a prognostic marker in judgement of malignant degree and prognosis in ovarian cancer patients.