Inhibitory effects of apogossypolone on subcutaneous implants of human LNCaP prostatic carcinoma cells

Objective The aim of this study was to investigate the inhibitory effect of apogossypolone (ApoG 2) on subcutaneous implants of human LNCaP prostatic carcinoma cells, and explore its mechanism. implants of human LNCaP prostatic carcinoma cells, and explore its mechanism. Methods To establish human LNCaP prostatic carcinoma cell line subcutaneous xenograft models and observe the inhibitory effect of ApoG2 on the tumor model. prostatic carcinoma cell line subcutaneous xenograft models and observe the inhibitory effect of ApoG 2 on the tumor model. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and-8 in tumor tissues. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and-8 in tumor tissues. The microvessel density was calculated. The microvessel density was calculated. Results ApoG 2 could obviously inhibit the growth of subcutaneous prostatic carcinoma implant. implant. ApoG 2 decreased the expression of PCNA and CD31, and increased the expression of caspases-3,-8 in tumor tissues. Conclusion ApoG2 has an inhibitory effect on prostatic carcinoma implants.