5-HT1B receptor knockout mice show no adaptive changes in 5-HT1A receptor function as measured telemetrically on body temperature and heart rate responses
Brain Research Bulletin(2002)
摘要
Two presynaptic receptors play an important role in the regulation of serotonergic neurotransmission, i.e., the 5-HT1A and 5-HT1B receptor. The present study focuses on putative adaptive changes in the 5-HT1A receptor system in mice that lack 5-HT1B receptors (5-HT1B KO). 5-HT1A receptor sensitivity was assessed in vivo in two models of presynaptic 5-HT1A receptor activity: agonist-induced hypothermia and prevention of stress-induced hyperthermia. The effects of 5-HT1A receptor activation by flesinoxan (0.1–3.0 mg/kg s.c.) were determined telemetrically on body temperature and heart rate in 5-HT1B KO and wild-type (WT) mice. Flesinoxan induced hypothermia dose-dependently without affecting heart rate and prevented stress-induced hyperthermia and tachycardia equipotently in both genotypes. Specificity of these responses was confirmed by blockade with the selective 5-HT1A receptor antagonist WAY100635 (1.0 mg/kg s.c.). The importance of continuous sampling in freely moving subjects to improve appropriate characterization of mutants is discussed. 5-HT1B KO mice showed no shift in 5-HT1A receptor sensitivity compared to WT mice. This study found no indications for adaptive changes in presynaptic 5-HT1A receptor function in 5-HT1B KO mice as measured telemetrically on body temperature and heart rate responses.
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关键词
Anxiety,Stress-induced hyperthermia,5-HT1A Receptor,5-HT1B Receptor knockout,Radiotelemetry,Heart rate
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