Multiple Primary Malignancies And Human Papilloma Virus Infections
MULTIPLE PRIMARY MALIGNANCIES(2009)
摘要
Patients may develop multiple primary malignancies (MPM) due to the occurrence of many known predisposing factors (i.e. genetic
background, environmental factors, hormonal unbalance, and acquired immunosuppression); however, in most cases, no obvious
cause of has been found [1–3]. During the last few decades, accumulating evidence has pointed to the involvement of human
papillomavirus (HPV) in the development of several neoplastic and preneoplastic lesions of anatomic sites beyond the uterine
cervix. In particular, HPV has been associated with squamous cell carcinomas and related precursors in the oral cavity, esophagus,
skin, larynx, conjunctiva, paranasal sinuses and bronchus, but even in non-Malpighian-derived tumors, such as urinary bladder
carcinoma. At least for a subset of these cases, it has been suggested that exposure to HPV can precede the appearance of
cancer by 10 or more years [4, 5]; nonetheless, the true prevalence of HPV DNA in pre-cancerous lesions remains uncertain.
更多查看译文
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要