Almitrine prevents some hypoxia-induced metabolic injury in rat astrocytes
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid(1993)
摘要
During reperfusion of ischemic brain tissue, the production of reactive oxygen species initiates several modifications of
the astroglial functional and ultrastructural integrity. During 24 h after ischemic treatment, modification of cellular superoxide
free radical scavenging systems have been observed in primary culture of rat astroglial cell. Mitochondrial Mn superoxide
dismutase activity (Mn-SOD) gradually decreases, whereas that of the cytosolic Cu,Zn form of the enzyme remains unaffected.
We observed in parallel a significant decrease of glutamine synthetase (GS), an astrocyte specifically located enzyme. Addition
of almitrine (dialylamine-4′,6′-triazinyl 2′)-l-(bis-parafluorobenzydryl)-4-piperazine or dibucaine (a phospholipase A2 inhibitor) antagonizes the decrease of Mn-SOD activity, but does not affect modification of GS activity. Combined effects
are observed by simultaneous addition of both drugs. Our data demonstrate that almitrine may increase the synthesis of some
mitochondrial proteins, like Mn-SOD, and provide support for further study on the therapeutic potential of almitrine in ischemic
astroglial cell injury.
更多查看译文
关键词
glutamine synthetase,oxygen radicals,dibucaine.,hypoxia,index entries: brain ischemia,astrocytes,superoxide dismutase,almi- trine,free radicals,free radical,enzyme,indexation
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要