The effects of methylprednisolone on postoperative bowel motility and propulsion in dogs
Diseases of the colon and rectum(2012)
摘要
Eighteen mongrel dogs underwent handsewn right segmental colectomy. One group was pretreated with methylprednisolone 30 mg/kg
intravenously at the time of surgery and 7.5 mg/kg intravenously at 6-hour intervals for 24 hours; the second group served
as a saline control. Motility was measured postoperatively by manometric catheters, and propulsion was measured by x-ray evidence
of passage of radiopaque markers. Marker studies showed more rapid passage in animals pretreated with steroids, but differences
were not statistically significant (P=0.11). Motility studies showed a significant overall increase in motility in steroid-treated animals on the first postoperative
day (P=0.03); smaller differences on the second or third days were not significant. Motility studies comparing ileum, cecum, and
sigmoid showed the ileum to be the site of significant steroid effect (P=0.02), with insignificant benefit seen in the colon. The data suggest that methylprednisolone may be of some objective benefit
in restoration of postoperative bowel motility, and the site of action may be in the small bowel and not at the anastomosis.
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关键词
corticosteroids,bowel and not at the anastomosis. key words: motility,bowel resection,methylpred- nisolone,statistical significance
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