Study on the changes of the coagulation state of severe trauma patients with intensive insulin treatment

Objective To study the influence of early intensive insulin treatment on the changes of coagulation state of severe trauma patients.Methods 138 severe trauma patients(ISS20)were randomly divided into intensive insulin treatment and control group,which were administered intensive and routine insulin respectively.The amount of insulin and blood glucose were noted every day,and PLT,DD,PC,PS,AT-Ⅲ,TM,TPA,PAI1,PT,TT,APTT and FBG were detected respectively.Results Average doses of insulin within a day in intensive insulin treatment were significantly higher than those in routine treatment group,but average blood glucose of intensive insulin treatment was lower than that of routine trement group.After controlled strictly blood glucose with intensive insulin treatment,APTT,PT and TT of intensive insulin treatment group shortened,but FBG rose(P0.05),PLT was higher.TM,PAI-1 and DD were lower(P0.05);PC,PS and TPA were higher in comparison with routine treatment group(P0.05).Conclusion Intensive insulin treatment can reduce the dysfunction of coagulation system in severe patients effectively.