Increased Central Artery Stiffness in Impaired Glucose Metabolism and Type 2 Diabetes

Abstract—Impaired glucose metabolism,(IGM) and type 2 diabetes (DM-2) are associated with high cardiovascular disease risk. Increases in peripheral and central artery stiffness may represent pathophysiologic pathways through which glucose tolerance status leads to cardiovascular disease. Peripheral artery stiffness increases with deteriorating glucose tolerance status, whereas this trend remains unclear for central artery stiffness. Therefore, we investigated the associations between,glucose tolerance status and estimates of central arterial stiffness. We performed,a population-based study of 619 individuals (normal glucose metabolism, n261; IGM, n170; and DM-2, n188) and assessed central artery