Effect of DNA from salmon milt on human skin conditions

We investigated the effect of rubbing the DNA-Na from salmon milt on human skin condition. A 3% DNA-Na cream or the control cream was rubbed onto the male subjects (ten/group) for 12 weeks. The results showed that the DNA cream improved skin-elasticity more than the control cream after the fourth week. The change in skin-elasticity was improved significantly. Rubbing of the DNA cream tended to decrease transepithelial water loss (TEWL) and to increase water content in the face skin at 12 weeks. In addition, according to the results of a questionnaire, more than 90% of the subjects who used the DNA cream felt improving roughness of the skin. In conclusion, these results showed that their skin conditions were improved by rubbing on the DNA-Na. We evaluated the promoting effect of the DNA-Na on the production of hyaluronic acid using human normal dermal fibroblasts. The results showed that the DNA-Na has the promoting effect of hyaluronic acid production on the fibroblasts. This data suggested that the DNA-Na would improve skin conditions.