Guidance for contained field trials of vector mosquitoes engineered to contain a gene drive system: recommendations of a scientific working group.

Vector-Borne and Zoonotic DiseasesVol. 8, No. 2 Genetically Engineered Mosquitoes: Field Trial Guidance DocumentOpen AccessGuidance for Contained Field Trials of Vector Mosquitoes Engineered to Contain a Gene Drive System: Recommendations of a Scientific Working GroupM. Benedict, P. D'Abbs, S. Dobson, M. Gottlieb, L. Harrington, S. Higgs, A. James, S. James, B. Knols, J. Lavery, S. O'Neill, T. Scott, W. Takken, and Y. ToureM. BenedictSearch for more papers by this author, P. D'AbbsSearch for more papers by this author, S. DobsonSearch for more papers by this author, M. GottliebSearch for more papers by this author, L. HarringtonSearch for more papers by this author, S. HiggsSearch for more papers by this author, A. JamesSearch for more papers by this author, S. JamesSearch for more papers by this author, B. KnolsSearch for more papers by this author, J. LaverySearch for more papers by this author, S. O'NeillSearch for more papers by this author, T. ScottSearch for more papers by this author, W. TakkenSearch for more papers by this author, and Y. ToureSearch for more papers by this authorPublished Online:1 May 2008https://doi.org/10.1089/vbz.2007.0273AboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited byRegulation of Transgenic Insects3 November 2022Risk Analysis of Transgenic Insects3 November 2022The principles driving gene drives for conservationEnvironmental Science & Policy, Vol. 135Opening up, closing down, or leaving ajar? How applications are used in engaging with publics about gene drive23 March 2022 | Journal of Responsible Innovation, Vol. 9, No. 2An Introduction to Containment Recommendations for Gene Drive Mosquitoes and the Laboratory Rearing of Genetically Engineered Mosquitoes in Africa Stephen Higgs13 January 2022 | Vector-Borne and Zoonotic Diseases, Vol. 22, No. 1Looking to the FutureGene-drive suppression of mosquito populations in large cages as a bridge between lab and field28 July 2021 | Nature Communications, Vol. 12, No. 1Culex quinquefasciatus: status as a threat to island avifauna and options for genetic control4 March 2021 | CABI Agriculture and Bioscience, Vol. 2, No. 1Sex separation of Aedes spp. mosquitoes for sterile insect technique application: a review24 July 2021 | Entomologia Experimentalis et Applicata, Vol. 169, No. 10Selection of sites for field trials of genetically engineered mosquitoes with gene drive10 August 2021 | Evolutionary Applications, Vol. 14, No. 9Gene drive strategies of pest control in agricultural systems: Challenges and opportunities4 August 2021 | Evolutionary Applications, Vol. 14, No. 9Oxitec and MosquitoMate in the United States: lessons for the future of gene drive mosquito control27 July 2021 | Pathogens and Global Health, Vol. 115, No. 6Advances in Aedes Mosquito Vector Control Strategies Using CRISPR/Cas91 January 2022Interdisciplinary development of a standardized introduction to gene drives for lay audiences5 November 2020 | BMC Medical Research Methodology, Vol. 20, No. 1Evaluating the probability of CRISPR‐based gene drive contaminating another species17 April 2020 | Evolutionary Applications, Vol. 13, No. 8Vector genetics, insecticide resistance and gene drives: An agent-based modeling approach to evaluate malaria transmission and elimination14 August 2020 | PLOS Computational Biology, Vol. 16, No. 8Measuring the Host-Seeking Ability of Aedes aegypti Destined for Field ReleaseThe American Journal of Tropical Medicine and Hygiene, Vol. 102, No. 1Genetic Control of Mosquitoes1 October 2020Alternative Techniques and Options for Risk Reduction of Gene Drives24 April 2020Steps Towards a Precautionary Risk Governance of SPAGE Technologies Including Gene-Drives24 April 2020Experimental population modification of the malaria vector mosquito, Anopheles stephensi19 December 2019 | PLOS Genetics, Vol. 15, No. 12A typology of community and stakeholder engagement based on documented examples in the field of novel vector control25 November 2019 | PLOS Neglected Tropical Diseases, Vol. 13, No. 11Knowledge engagement in gene drive research for malaria control25 April 2019 | PLOS Neglected Tropical Diseases, Vol. 13, No. 4The Revised Arthropod Containment Guidelines Stephen Higgs27 February 2019 | Vector-Borne and Zoonotic Diseases, Vol. 19, No. 3Dispersal and survival of radio-sterilised male Aedes albopictus Skuse (Diptera: Culicidae) and estimation of the wild populations in view of an sterile insect technique programme in Pointe des Lascars, Mauritius28 February 2019 | International Journal of Tropical Insect Science, Vol. 39, No. 1Genetic Modification of Pest and Beneficial Insects for Pest Management ProgramsControlling vector-borne diseases by releasing modified mosquitoes18 May 2018 | Nature Reviews Microbiology, Vol. 16, No. 8Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group †The American Journal of Tropical Medicine and Hygiene, Vol. 98, No. 6_SupplHarnessing gene drive28 December 2017 | Journal of Responsible Innovation, Vol. 5, No. sup1Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods Mark Q. Benedict, Austin Burt, Margareth L. Capurro, Paul De Barro, Alfred M. Handler, Keith R. Hayes, John M. Marshall, Walter J. Tabachnick, and Zach N. Adelman1 January 2018 | Vector-Borne and Zoonotic Diseases, Vol. 18, No. 1Containment Studies of Transgenic Mosquitoes in Disease Endemic Countries: The Broad Concept of Facilities Readiness M. Megan Quinlan, Josephine Birungi, Mamadou B. Coulibaly, Abdoulaye Diabaté, Luca Facchinelli, Wolfgang Richard Mukabana, James Mutuku Mutunga, Tony Nolan, Peter Raymond, and Sékou F. Traoré1 January 2018 | Vector-Borne and Zoonotic Diseases, Vol. 18, No. 1Studies of Transgenic Mosquitoes in Disease-Endemic Countries: Preparation of Containment Facilities M. Megan Quinlan, James Mutuku Mutunga, Abdoulaye Diabaté, Moussa Namountougou, Mamadou B. Coulibaly, Lakamy Sylla, Jonathan Kayondo, Victor Balyesima, Lorna Clark, Mark Q. Benedict, and Peter Raymond1 January 2018 | Vector-Borne and Zoonotic Diseases, Vol. 18, No. 1Community Engagement and Field Trials of Genetically Modified Insects and Animals19 February 2018 | Hastings Center Report, Vol. 48, No. 1Developing standard operating procedures for gene drive research in disease vector mosquitoes19 January 2018 | Pathogens and Global Health, Vol. 111, No. 8The promise and peril of CRISPR gene drives1 September 2017 | BioEssays, Vol. 39, No. 10Rules of the road for insect gene drive research and testing8 August 2017 | Nature Biotechnology, Vol. 35, No. 8Towards the genetic control of invasive species21 February 2017 | Biological Invasions, Vol. 19, No. 6Meeting Report: Translational Considerations of Novel Vector Management Approaches11 August 2016 | PLOS Neglected Tropical Diseases, Vol. 10, No. 8Considerations for Disrupting Malaria Transmission in Africa Using Genetically Modified Mosquitoes, Ecology of Anopheline Disease Vectors, and Current Methods of ControlExploring the Sex-Determination Pathway for Control of Mosquito-Borne Infectious DiseasesRegulation of Transgenic MosquitoesEconomic Analysis of Genetically Modified Mosquito StrategiesImpact of Genetic Modification of Vector Populations on the Malaria Eradication AgendaEngaging scientists: An online survey exploring the experience of innovative biotechnological approaches to controlling vector-borne diseases10 August 2015 | Parasites & Vectors, Vol. 8, No. 1Site-Specific Cassette Exchange Systems in the Aedes aegypti Mosquito and the Plutella xylostella Moth1 April 2015 | PLOS ONE, Vol. 10, No. 4Antipathogen genes and the replacement of disease‐vectoring mosquito populations: a model‐based evaluation10 October 2014 | Evolutionary Applications, Vol. 7, No. 10The use of modified mosquitoes in Brazil for the control of Aedes aegypti: methodological and ethical constraintsCadernos de Saúde Pública, Vol. 30, No. 11Regulating gene drives17 July 2014 | Science, Vol. 345, No. 6197Hybridization studies to modify the host preference of Anopheles gambiae29 August 2014 | Medical and Veterinary Entomology, Vol. 28, No. S1Concerning RNA-guided gene drives for the alteration of wild populations17 July 2014 | eLife, Vol. 3Heritable strategies for controlling insect vectors of disease19 June 2014 | Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 369, No. 1645Criteria for Identifying and Evaluating Candidate Sites for Open-Field Trials of Genetically Engineered Mosquitoes David M. Brown, Luke S. Alphey, Andrew McKemey, Camilla Beech, and Anthony A. James10 April 2014 | Vector-Borne and Zoonotic Diseases, Vol. 14, No. 4Guidelines to site selection for population surveillance and mosquito control trials: A case study from MauritiusActa Tropica, Vol. 132Framework for rapid assessment and adoption of new vector control toolsTrends in Parasitology, Vol. 30, No. 4Ethical Issues in Field Trials of Genetically Modified Disease-Resistant Mosquitoes21 December 2012 | Developing World Bioethics, Vol. 14, No. 1A Regulatory Structure for Working with Genetically Modified Mosquitoes: Lessons from Mexico13 March 2014 | PLoS Neglected Tropical Diseases, Vol. 8, No. 3Genetic control of Aedes mosquitoes3 December 2013 | Pathogens and Global Health, Vol. 107, No. 4Guidance on the environmental risk assessment of genetically modified animalsEFSA Journal, Vol. 11, No. 5Population impacts of Wolbachia on Aedes albopictusEcological Applications, Vol. 23, No. 2Field Cage Studies and Progressive Evaluation of Genetically-Engineered Mosquitoes17 January 2013 | PLoS Neglected Tropical Diseases, Vol. 7, No. 1Genetic Modification of Pest and Beneficial Insects for Pest-Management ProgramsAssessing the Feasibility of Controlling Aedes aegypti with Transgenic Methods: A Model-Based Evaluation21 December 2012 | PLoS ONE, Vol. 7, No. 12Confinement of gene drive systems to local populations: A comparative analysisJournal of Theoretical Biology, Vol. 294Scientific Standards and the Regulation of Genetically Modified Insects31 January 2012 | PLoS Neglected Tropical Diseases, Vol. 6, No. 1Development of a Semi-Field System for Contained Field Trials with Aedes aegypti in Southern MexicoThe American Journal of Tropical Medicine and Hygiene, Vol. 85, No. 2A Secure Semi-Field System for the Study of Aedes aegypti22 March 2011 | PLoS Neglected Tropical Diseases, Vol. 5, No. 3Semele : A Killer-Male, Rescue-Female System for Suppression and Replacement of Insect Disease Vector Populations1 February 2011 | Genetics, Vol. 187, No. 2Genetics-Based Field Studies Prioritize SafetyScience, Vol. 331, No. 6016Perspectives of people in Mali toward genetically-modified mosquitoes for malaria control14 May 2010 | Malaria Journal, Vol. 9, No. 1Health research ethics in malaria vector trials in Africa13 December 2010 | Malaria Journal, Vol. 9, No. S3Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative GenomicsScience, Vol. 330, No. 6000Defining Environment Risk Assessment Criteria for Genetically Modified Insects to be placed on the EU MarketEFSA Supporting Publications, Vol. 7, No. 8Current outline of regulation of Bt-maize and transgenic insects in MexicoEntomological Research, Vol. 40, No. 1A lethal ovitrap-based mass trapping scheme for dengue control in Australia: II. Impact on populations of the mosquito Aedes aegyptiMedical and Veterinary Entomology, Vol. 23, No. 4The effect of gene drive on containment of transgenic mosquitoesJournal of Theoretical Biology, Vol. 258, No. 2Chapter 4 Evolutionary Drivers of Parasite‐Induced Changes in Insect Life‐History TraitsEstablishment of a large semi-field system for experimental study of African malaria vector ecology and control in Tanzania20 August 2008 | Malaria Journal, Vol. 7, No. 1 Volume 8Issue 2Apr 2008 InformationMary Ann Liebert, Inc.To cite this article:M. Benedict, P. D'Abbs, S. Dobson, M. Gottlieb, L. Harrington, S. Higgs, A. James, S. James, B. Knols, J. Lavery, S. O'Neill, T. Scott, W. Takken, and Y. Toure.Guidance for Contained Field Trials of Vector Mosquitoes Engineered to Contain a Gene Drive System: Recommendations of a Scientific Working Group.Vector-Borne and Zoonotic Diseases.Apr 2008.127-166.http://doi.org/10.1089/vbz.2007.0273creative commons licensePublished in Volume: 8 Issue 2: May 1, 2008Online Ahead of Print:April 12, 2008PDF download