Aquatic birnavirus induces necrotic cell death via the mitochondria-mediated caspase pathway

    Fish & shellfish immunology, Volume 28, Issue 2, 2010, Pages 344-353.

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    Keywords:
    caspasemitochondrial membrane potentialcell deathsignaling pathway

    Abstract:

    Aquatic birnavirus induces necrotic cell death by an ill-understood process. Presently, we demonstrate that infectious pancreatic necrosis virus (IPNV) induces post-apoptotic necrotic cell death through loss of mitochondrial membrane potential (MMP) followed by caspase-3 activation in CHSE-214 cells. Progressive phosphatidylserine externa...More

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