A Machine Learning Model Based on Preoperative Multiparametric Quantitative DWI Can Effectively Predict the Survival and Recurrence Risk of Pancreatic Ductal Adenocarcinoma.

Abstract Purpose To develop a machine learning (ML) model combining preoperative multiparametric diffusion-weighted imaging (DWI) and clinical features to better predict overall survival (OS) and recurrence-free survival (RFS) following radical surgery for pancreatic ductal adenocarcinoma (PDAC). Materials and methods A retrospective analysis was conducted on 234 PDAC patients who underwent radical resection at two centers. Among 101 ML models tested for predicting postoperative OS and RFS, the best-performing model was identified based on comprehensive evaluation metrics, including C-index, Brier scores, AUC curves, clinical decision curves, and calibration curves. This model’s risk stratification capability was further validated using Kaplan–Meier survival analysis. Results The random survival forest model achieved the highest C-index (0.828/0.723 for OS and 0.781/0.747 for RFS in training/validation cohorts). Incorporating nine key factors—D value, T-stage, ADC-value, postoperative 7th day CA19-9 level, AJCC stage, tumor differentiation, type of operation, tumor location, and age—optimized the model’s predictive accuracy. The model had integrated Brier score below 0.13 and C/D AUC values above 0.85 for both OS and RFS predictions. It also outperformed traditional models in predictive ability and clinical benefit, as shown by clinical decision curves. Calibration curves confirmed good predictive consistency. Using cut-off scores of 16.73/29.05 for OS/RFS, Kaplan–Meier analysis revealed significant prognostic differences between risk groups (p < 0.0001), highlighting the model’s robust risk prediction and stratification capabilities. Conclusion The random survival forest model, combining DWI and clinical features, accurately predicts survival and recurrence risk after radical resection of PDAC and effectively stratifies risk to guide clinical treatment. Critical relevance statement The construction of 101 ML models based on multiparametric quantitative DWI combined with clinical variables has enhanced the prediction performance for survival and recurrence risks in patients undergoing radical resection for PDAC. Key Points This study first develops DWI-based radiological–clinical ML models predicting PDAC prognosis. Among 101 models, RFS is the best and outperforms other traditional models. Multiparametric DWI is the key prognostic predictor, with model interpretations through SurvSHAP. Graphical Abstract