Preparation and Characterization of Microcapsules and Tablets for Probiotic Encapsulation Via Whey Protein Isolate-Nanochitin Complex Coacervation

Mengxin Luo,Le Ma, Yuxi Guo, Caihong Zhu, Junjie Chen,Bin Zhang, Jianguo Zhu,Matt Jellicoe,Shan He, Yucong Zou,Yang Yuan

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES（2025）

Guangzhou Univ

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Abstract

This research delved into the feasibility of utilizing three nanochitin—chitin nanocrystal (CNC), chitin nanofiber (CNF), and chitin nanosphere (CNS) in complexation with whey protein isolate (WPI) to fabricate complex coacervation and create microcapsules for probiotic encapsulation. The results showed that CNC, CNF, and CNS exhibited notable differences in morphologies, dimensions, and properties due to the respective synthesis methodologies. Nevertheless, all of them maintained a positive charge and were capable of assembling into microcapsules with WPI via electrostatic interactions at optimal pHs. The inclusion of Lactobacillus casei (L. casei) during the complex coacervation phase engendered a shell-like formation around the bacterium within the microcapsule, which enhanced probiotic viability and increased colony-forming unit count. Additionally, these probiotic-loading microcapsules were also processed into tablets, displaying robust structural integrity, augmented protective capabilities, and a distinctive sustained-release profile compared to the microcapsules alone. In summary, this study pioneered the employment of nanochitin formulations in complex coacervation to encapsulate L. casei, spearheading an innovative approach to the creation of a compressed probiotic supplement and contributing to the advancement in the design and fabrication of encapsulation vehicles for active ingredients.

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Key words

Complex coacervation,Nanochitin,Whey protein isolate,Microencapsulation,Probiotic

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【要点】：研究利用三种纳米壳聚糖（纳米壳聚糖粒子、纳米壳聚糖纤维和纳米壳聚糖球体）与乳清蛋白分离物复合共凝聚法制备微囊，实现对益生菌的保护和缓释，为益生菌补充剂的设计与制造提供了创新方法。

【方法】：通过静电作用在最佳pH值下，将纳米壳聚糖与乳清蛋白分离物结合，形成复合共凝聚体，用于益生菌的微囊封装。

【实验】：实验使用Lactobacillus casei (L. casei) 作为益生菌模型，通过微囊封装后制成片剂，并评估了其结构完整性、保护能力和缓释特性；数据集名称未在文本中提及，故无法提供。