Improving Neurological Health in Aging Via Neuroplasticity-BasedComputerized Exercise:Protocol for a Randomized ControlledTrial
JMIR RESEARCH PROTOCOLS（2024）
Posit Sci Corp
Abstract
Background: Our current understanding of how computerized brain training drives cognitive and functional benefits remainsincomplete. This paper describes the protocol for Improving Neurological Health in Aging via Neuroplasticity-based ComputerizedExercise (INHANCE), a randomized controlled trial in healthy older adults designed to evaluate whether brain training improvescholinergic signaling.Objective: INHANCE evaluates whether 2 computerized training programs alter acetylcholine binding using the vesicularacetylcholine transporter ligand [18F] fluoroethoxybenzovesamicol ([18F] FEOBV) and positron emission tomography (PET).Methods: In this phase IIb, prospective, double-blind, parallel-arm, active-controlled randomized trial, a minimum of 92community-dwelling healthy adults aged 65 years and older are randomly assigned to a brain training program designed usingthe principles of neuroplasticity (BrainHQ by Posit Science) or to an active control program of computer games designed forentertainment (eg, Solitaire). Both programs consist of 30-minute sessions, 7 times per week for 10 weeks (35 total hours),completed remotely at home using either loaned or personal devices. The primary outcome is the change in FEOBV binding inthe anterior cingulate cortex, assessed at baseline and posttest. Exploratory cognitive and behavioral outcomes sensitive toacetylcholine are evaluated before, immediately after, and 3 months following the intervention to assess the maintenance ofobserved effects.Results: The trial was funded in September 2019. The study received approval from the Western Institutional Review Boardin October 2020 with Research Ethics Board of McGill University Health Centre and Health Canada approvals in June 2021.The trial is currently ongoing. The first participant was enrolled in July 2021, enrollment closed when 93 participants wererandomized in December 2023, and the trial will conclude in June 2024. The study team will be unblinded to conduct analysesafter the final participant exits the study. We expect to publish the results in the fourth quarter of 2024.Conclusions: There remains a critical need to identify effective and scalable nonpharmaceutical interventions to enhancecognition in older adults. This trial contributes to our understanding of brain training by providing a potential neurochemicalexplanation of cognitive benefit.
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Key words
brain training,cognitive training,healthy aging,neuroplasticity,acetylcholine,FEOBV,randomized controlled trial,aging,ageing,elderly,elder,older adults,older adult,neurological health,cognitive,computerized brain training,computerize,cognition,cognitive decline,Canada
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