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    • Frailty Detection with Routine Blood Tests Using Data from the English Longitudinal Study of Ageing (ELSA)

    Lingxiao He,Jinzhu Yang, Shujing Lin,Kanglin Shi,Ya Fang

    European Geriatric Medicine（2024）

    Xiamen University

    Cited 0|Views5
    Abstract
    To explore the possibility of frailty screening and monitoring using blood factors obtained from routine blood tests. At cross sectional level, mean corpuscular haemoglobin, HDL, triglyceride, ferritin, hsCRP, dehydroepiandrosterone, haemoglobin, and WBC were associated with frailty. At the longitudinal level, higher baseline concentrations of triglyceride, WBC, and lower HDL were linked to a greater risk of developing frailty within 10 years. Compared to adults without abnormal blood factors at baseline, the hazard ratios of participants with two or more abnormal blood factors were almost 2 fold higher in developing frailty over time. Routine blood factors could be used for frailty screening in clinical practice and estimate the development of frailty over time. Frailty is a rising global health issue in ageing society. Easily accessible and sensitive tools are needed for frailty monitoring while routine blood factors can be potential candidates. Data from 1907 participants (aged 60 years or above) were collected from the 4th to 9th wave of the English longitudinal study of ageing. 14 blood factors obtained from blood tests were included in the analysis. A 52-item frailty index (FI) was calculated for frailty evaluation. Logistic regression and Cox proportional hazards analysis were used to explore the relationships between baseline blood factors and the incidence of frailty over time respectively. All analyses were controlled for age and sex. The mean age of participants was 67.3 years and 47.2
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    Key words
    Ageing,Frailty detection,Blood factors,Routine
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