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    • The Effect of a Selenium-Based Anti-Inflammatory Strategy on Postoperative Functional Recovery in High-Risk Cardiac Surgery Patients - A Nested Sub-Study of the Sustain CSX Trial

    Life Sciences（2024）

    Deutsch Herzzentrum Charite

    Cited 0|Views9
    Abstract
    Aim: The cardiac surgery-related ischemia-reperfusion-related oxidative stress triggers the release of cytotoxic reactive oxygen and nitrogen species, contributing to organ failure and ultimately influencing patients' short- and long-term outcomes. Selenium is an essential co-factor for various antioxidant enzymes, thereby contributing to the patients' endogenous antioxidant and anti-inflammatory defense mechanisms. Given these selenium's pleiotropic functions, we investigated the effect of a high-dose selenium-based anti-inflammatory perioperative strategy on functional recovery after cardiac surgery. Materials and methods: This prospective study constituted a nested sub-study of the SUSTAIN CSX trial, a doubleblinded, randomized, placebo-controlled multicenter trial to investigate the impact of high-dose selenium supplementation on high-risk cardiac surgery patients' postoperative recovery. Functional recovery was assessed by 6-min walk distance, Short Form-36 (SF-36) and Barthel Index questionnaires. the patients were male. The mean (SD) predicted 30-day mortality by the European System for Cardiac Operative
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    Key words
    Selenium,Nutrition,Inflammation,Anti-inflammatory strategies,Functional recovery,Cardiac surgery
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