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Potential application of bulk RNA sequence in MPNs clinic routine

crossref(2024)

Chongqing Medical University

Cited 0|Views11
Abstract
Abstract Philadelphia chromosome negative myeloproliferative neoplasms is a chronic hematological malignancy caused by driven mutations and non-driven mutations. It is considered tumor inflammatory disease, which characterized by dysregulated immune system including aberrant cytokine and abnormal immune cell. A comprehensive view of gene mutation and immune state for each classic myeloproliferative neoplasm patient during different disease stages is highly valuable in guiding treatment choice. Single cell RNA sequence, spatial transcriptome, mass cytometer and multiplex immune staining are very performant in exploring integrative gene mutation and/or immune landscape in oncology, However, they are not used in clinic routine because of its high cost and/or its high dependance of expertise. Bulk RNA sequence could be widely used in clinic with advantage of relative low cost. Furthermore, bioinformatic science progress rends possible to identify gene mutation and immune related genes with bulk RNA sequences simultaneously, this work aims to explore the potential value in interpretating gene mutation and immune landscapes of classic myeloproliferative neoplasm with bulk RNA sequence.
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