Csl-Mtfl: Multi-task Feature Learning with Joint Correlation Structure Learning for Alzheimer’s Disease Cognitive Performance Prediction

Alzheimer’s disease (AD) is a common chronic neurodegenerative disease and the accurate prediction of the clinical cognitive performance is important for diagnosis and treatment. Recently, multi-task feature learning (MTFL) methods with sparsity-inducing regularization have been widely investigated on cognitive performance prediction tasks. Although they have proved to achieve improved performance compared with single-task learning, the major challenges are still not fully resolved. They involve how to capture the non-linear correlation among the tasks or features, and how to introduce the learned correlation for guiding the MTFL learning. To resolve these challenges, we introduce a correlation structure learning method through self-attention learning and sequence learning for jointly capturing the complicated but more flexible relationship for features and tasks, respectively. Moreover, we develop a dual graph regularization to encode the inherent correlation and an efficient optimization algorithm for solving the nonsmooth objective function. Extensive results on the ADNI dataset demonstrate that the proposed joint training framework outperforms existing methods and achieves state-of-the-art prediction performance of AD. Specifically, the proposed algorithm achieves an nMSE (normalized Mean Squared Error)/wR (weighted R-value) of 3.808/0.438, obtaining a relative improvement of 3.84 % /7.35 % compared with the MTFL method.