MoS2/organics superlattices for surface-enhanced supra-Nernstian biochemical detection

The development of highly sensitive nanoelectronic biochemical sensors based on 2D materials with extraordinary electrical proper-ties has aroused profound interest for potential applications including environmental monitoring and medical diagnosis. Herein, by purposefully connecting the source and drain electrodes at a fresh cleavage surface of a MoS2/hexadecyl trimethyl ammonium bromide (CTAB) superlattice with large anisotropic conductivities, we are able to limit current conduction near the surface for quick prototyping of electrolyte-gated quasi-2D/organic superlattice transistors in a few minutes. The sensing response of the hybrid superlattice transistor to biomolecules has surpassed the Nernst limit at room temperature due to its layer-by-layer nature and the plentiful heterostructures. The confined current flow and the excep-tional sensing response have provided an outstanding limit of detection down to a 10-16 M concentration with single-strand DNA molecular adsorption. Surface-enhanced current approaches in 2D/organic hybrid superlattices can be used to amplify small signals typical for biochemical detection on the nanoscale.