Persistence of immunological memory as a potential correlate of long-term, vaccine-induced protection against Ebola virus disease in humans.

Chelsea McLean, Karin Dijkman,Auguste Gaddah,Babajide Keshinro, Michael Katwere,Macaya Douoguih,Cynthia Robinson,Laura Solforosi,Dominika Czapska-Casey,Liesbeth Dekking,Yvonne Wollmann,Ariane Volkmann,Maria Grazia Pau,Benoit Callendret,Jerry Sadoff,Hanneke Schuitemaker,Roland Zahn,Kerstin Luhn,Jenny Hendriks,Ramon Roozendaal

Frontiers in immunology（2023）

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摘要

Humans infected with Ebola virus may benefit from the anamnestic response to prevent disease progression, as the incubation time is longer and progression of Ebola virus disease is slower as compared to non-human primates. Therefore, the persistence of vaccine-induced immune memory could be considered as a potential correlate of long-term protection against Ebola virus disease in humans, without the need for a booster.

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Ebola, vaccine, immunological memory, persistence, correlate, protection

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