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    • Ultra-trace Level Colorimetric Composite Sensor Based on Novel DH-1,6-NAPY-8-CN-AgNPs for the Detection of Clonazepam in Aqueous and Human Plasma Samples

    Shujaat Ali,Abdul Rehman Umar,Kashif Hussain,Haji Muhammad,Muddasir Hanif,Mouna Hind Laiche,Sufian Rasheed,Kousar Yasmeen,Abdul Hameed,Muhammad Raza Shah

    JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY（2023）

    Univ Karachi

    Cited 7|Views4
    Abstract
    It's crucial to develop cost-effective, rapid & reliable detection methods of specific analytes through sen-sors useful in the analytical and medicinal chemistry. We report a highly sensitive and selective colori-metric method for the detection of clonazepam by the new composite sensor DH-1,6-NAPY-8-CN-AgNPs containing 5-amino-7-(4-benzylpiperazin-1-yl)-2,4-bis(4-bromophenyl)-2-methyl-1,3-dihydro-1 ,6-naphthyridine-8-carbonitrile capped silver nanoparticles (AgNPs). The detection mechanism is based on the H-bonding interactions between clonazepam and the sensor, that caused the aggregation of NPs that initiated a sharp color change from yellow to red. The linear relationship between the adjacent absorbance values (DA) vs. clonazepam concentration (range = 0.05-75 lM) showed a correlation coef-ficient of 0.9927. The limit of detection (LOD) was 3 nM, that is very significant achievement over the existing reports. The proposed sensor is highly selective, with no interference from many other possible interfering substances. The sensor was successfully applied to the aqueous and human plasma samples, therefore DH-1,6-NAPY-8-CN-AgNPs demonstrated great potential for the on-site and real-time screen-ing of Clonazepam.& COPY; 2023 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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    Clonazepam detection,Composite sensor,DH-1,6-NAPY-8-CN-AgNPs,Aggregation,Colorimetric sensor,On-site drug screening
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